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Spindle-cell carcinoma: a case report.

R J Middlehurst1, C W Blackburn, P Sloan

  • 1Department of Oral and Maxillofacial Surgery, Turner Dental School, University Dental Hospital, Manchester.

The British Journal of Oral & Maxillofacial Surgery
|April 1, 1990
PubMed
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This case report details a rare spindle-cell carcinoma of the maxilla originating from erythroplakia. The tumor exhibited aggressive, infiltrative growth and suggested a multicentric origin, highlighting diagnostic and treatment challenges.

Area of Science:

  • Oral pathology
  • Oncology
  • Head and neck cancer research

Background:

  • Spindle-cell carcinoma is a rare malignancy.
  • Erythroplakia is a precancerous lesion.
  • Maxillary tumors present unique surgical challenges.

Observation:

  • An unusual exophytic spindle-cell carcinoma of the maxilla arose from erythroplakia.
  • Tumor recurred after initial surgery, showing extensive infiltration and rapid destruction.
  • Magnetic resonance imaging (MRI) indicated invasive tumor in the contralateral maxillary antrum.

Findings:

  • Electron microscopy and immunohistochemistry confirmed the epithelial origin of spindle cells.
  • The recurrent tumor demonstrated aggressive, infiltrative, and destructive behavior.

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  • Evidence suggested a potential multicentric origin of the maxillary carcinoma.

    • Implications:

    • This case underscores the importance of vigilant follow-up for maxillary tumors.
    • Accurate diagnosis and staging are critical for managing aggressive spindle-cell carcinomas.
    • Multicentricity should be considered in recurrent or extensive maxillary malignancies.