Acquisition-weighted chemical shift imaging improves SLOOP quantification of human cardiac phosphorus metabolites
Oliver Geier1, Andreas Max Weng2, Andreas Toepell2
1The Intervention Centre, Oslo University Hospital, Oslo, Norway; Institute of Radiology, University of Würzburg, Würzburg, Germany.
Purpose:
Phosphorous metabolite ratios in human myocardium were determined by a combination of acquisition weighted CSI and a SLOOP evaluation and the results were compared to corresponding SLOOP experiments using standard CSI.
Materials And Methods:
10 healthy subjects were examined at 1.5 T using both standard CSI and acquisition weighted CSI. Both experiments were performed with a similar acquisition time and the same spatial resolution. The PCr/ATP ratio was determined and the localization properties of both experiments were compared.
Results:
The PCr/ATP ratio of 2.2±0.4 found for the experiment using acquisition weighted CSI was almost identical to the value of 2.0±0.4 for standard CSI. The sensitivity and the localization properties improved in all subjects using SLOOP evaluation of the acquisition weighted sampling in comparison to the standard CSI acquisition with an average of 3% and 18%, respectively.
Conclusion:
The employment of acquisition weighting allows for a further improvement of the (31)P SLOOP spectroscopy of the human heart.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:20¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)