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Published on: February 12, 2021
Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction
Mark D Tarn1, Giancarlo Pascali, Francesco De Leonardis
1Department of Chemistry, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.
Journal of Chromatography. A
|February 5, 2013
Summary
Microfluidic devices can now purify positron emission tomography (PET) radiotracers like 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) using on-chip solid-phase extraction. This miniaturized approach achieves high radiochemical purity, enhancing PET tracer production.
Area of Science:
- Radiochemistry
- Microfluidics
- Nuclear Medicine
Background:
- Microfluidic devices offer miniaturization potential for positron emission tomography (PET) radiotracer production.
- Current microfluidic applications primarily focus on synthesis, neglecting purification and pre-concentration steps.
Purpose of the Study:
- To develop microfluidic modules for the purification of PET radiotracers.
- To demonstrate the efficacy of on-chip solid-phase extraction (SPE) for radiotracer purification.
Main Methods:
- Development of microfluidic modules incorporating SPE.
- Application of these modules for the purification of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG).
Main Results:
- Achieved up to 90% radiochemical purity for [18F]FDG using the developed SPE microfluidic modules.
- Demonstrated the feasibility of miniaturized purification for PET radiotracers.
Conclusions:
- Microfluidic SPE modules are effective for PET radiotracer purification.
- Further methods can be explored to increase radiochemical purity for enhanced PET imaging applications.
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