Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants

Drugs Acting on Autonomic Ganglia: Stimulants

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Repeated Clozapine Administration Causes Extensive Changes to the Expression of Coding and Non-coding RNAs, Including miR-124, in the Mouse Frontal Cortex.

Molecular neurobiology·2025

Same author

Monoamine receptors targeted by methamphetamine differentially modulate basal and fentanyl-depressed respiration in mice.

Pharmacology, biochemistry, and behavior·2025

Same author

Characterization and validation of a spontaneous acute and protracted oxycodone withdrawal model in male and female mice.

Pharmacology, biochemistry, and behavior·2024

Same author

Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice.

Pharmacology, biochemistry, and behavior·2024

Same author

Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.

Pharmacology, biochemistry, and behavior·2023

Same author

Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.

Pharmacology, biochemistry, and behavior·2023

Search research articles

Related Experiment Video

Updated: May 14, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Glial cell modulators attenuate methamphetamine self-administration in the rat.

Sarah E Snider¹, Elizabeth S Hendrick, Patrick M Beardsley

¹Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.

European Journal of Pharmacology

|February 5, 2013

Summary

Targeting glial cells with ibudilast, AV1013, or minocycline reduced methamphetamine self-administration in rats. These findings suggest potential new therapies for methamphetamine abuse by modulating neuroinflammation.

More Related Videos

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Related Experiment Videos

Last Updated: May 14, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Area of Science:

Neuroscience
Pharmacology
Addiction Research

Background:

Neuroinflammation, driven by activated microglia and astrocytes, is linked to drug abuse behaviors.
Methamphetamine use activates glial cells, increasing pro-inflammatory cytokines and contributing to addiction-related behaviors.

Purpose of the Study:

To investigate if ibudilast, AV1013, or minocycline could reduce active methamphetamine self-administration in rats.
To assess the potential of targeting glial activation as a therapeutic strategy for methamphetamine abuse.

Main Methods:

Rats were trained to self-administer methamphetamine intravenously.
Ibudilast, AV1013, or minocycline were co-administered with methamphetamine during self-administration sessions.
Changes in responding (lever presses) were measured to quantify drug intake.

Main Results:

Ibudilast, AV1013, and minocycline significantly reduced methamphetamine self-administration at a specific dose (0.03 mg/kg/inf).
These effects were observed in rats that previously maintained high levels of drug intake.

Conclusions:

Targeting glial cells with compounds like ibudilast, AV1013, and minocycline shows promise in attenuating methamphetamine self-administration.
Modulating neuroinflammation via glial cell pathways may offer a novel pharmacotherapeutic approach for treating methamphetamine addiction.