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Isolation of Murine Lymph Node Stromal Cells
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Published on: August 19, 2014

Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors

Miho Sekai1, Shizue Tani-ichi, Mitsutoshi Yoneyama

  • 1Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

Molecular Immunology
|February 5, 2013
PubMed
Summary

Lymphocyte and stromal cell interactions induce Interleukin-7 (IL-7) production in stromal cells. This process involves Interferon Regulatory Factors (IRFs) and Interferon-stimulated Response Elements (ISREs), suggesting a role for type I Interferons (IFNs) in lymphocyte development.

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