[Interrelations between hemopoietic microenvironment, osteogenesis and hemopoiesis under the effects of estrone]

The effect of estrone injections on heterotopic marrow organ formation and femoral hemopoiesis and osteogenesis was studied in C57B1 X CBAF1 mice. Estrone injections resulted in decreased hemopoiesis in femoral marrow, its fibrosis and reduced cellularity of heterotopic organ. Any correlations between osteogenic and hematopoietic tissue were not revealed.