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Updated: May 14, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
[Instrumental therapy of drug-resistant hypertension]
Gábor Simonyi1, J Róbert Bedros, Mihály Medvegy
1Pest Megyei Flór Ferenc Kórház, Kardiometabolikus Centrum V. Belgyógyászat, Lipidológiai Osztály és Nefrológiai Részleg.
Abstract:
It is well known that hypertension is an independent cardiovascular risk factor. Treatment of hypertension frequently includes administration of three or more drugs. Resistant hypertension is defined when blood pressure remains above target value despite full doses (the patient's maximum tolerated dose) of antihypertensive medication consisting of at least three different classes of drugs including a diuretic. Pharmacological treatment of hypertension is often unsuccessful despite the increasing number of drug combinations. Uncontrolled hypertension, however, increases the cardiovascular risk. Instrumental treatment of resistant hypertension is currently testing two major fields. One is the stimulation of baroreceptors in the carotid sinus and the other is radiofrequency ablation of sympathetic nerve fibers around renal arteries to reduce blood pressure in drug resistant hypertension.
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