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Updated: May 14, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
Published on: September 25, 2016
Osmotic regulation of seamless tube growth
Jodi Schottenfeld-Roames1, Amin S Ghabrial
1Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.
Abstract:
Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.
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