Related Experiment Video
Updated: May 14, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Published on: July 12, 2021
Febrile seizures. Update and controversies
Mohammed M Jan1, John P Girvin
1Department of Neurosciences, King Faisal Specialist Hospital & Research Centre, MBC J-76, PO Box 40047, Jeddah 21499, Kingdom of Saudi Arabia. Tel. +966 (2) 6677777 Ext. 5819. Fax. +966 (2) 6677777 Ext. 5813.
Insights
Febrile seizures are common in young children and usually benign. Recent evidence suggests pediatricians are becoming more selective in investigations, as extensive workups for febrile seizures often yield low results.
Area of Science:
- Pediatrics
- Neurology
Background:
- Febrile seizures are the most common seizure disorder in children under 5.
- Most cases are brief, have benign prognoses, and do not require specific treatment.
- Physicians often manage parental anxiety and make decisions about investigations and treatment.
Purpose of the Study:
- To provide an updated overview of febrile seizures.
- To review current diagnostic and therapeutic recommendations.
- To address variations in physician evaluation and management.
Main Methods:
- Review of recent evidence and diagnostic/therapeutic recommendations for febrile seizures.
- Analysis of physician practices regarding investigation and management.
- Evaluation of the yield of investigations in altering management.
Main Results:
- Despite understanding, physician management of febrile seizures varies.
- Pediatricians are increasingly selective in admitting and investigating children with febrile seizures.
- Children admitted often present with complex seizures, status epilepticus, or appear ill.
Conclusions:
- The yield of investigations for febrile seizures remains low.
- Extensive work-ups and prolonged hospitalizations are often not justified.
- Selective evaluation and management are becoming more prevalent.
Abstract:
Febrile seizures are the most common seizure disorder in children younger than 5 years of age. Most febrile seizures are brief, do not require any specific treatment or workup, and have benign prognoses. Generalists and pediatricians are frequently faced with anxious parents and are required to make rational decisions regarding the need to investigate and treat such a child. They subsequently need to provide further prognostic information and counseling to the families. The aim of this article is to provide an updated overview of febrile seizures and review the most recent diagnostic and therapeutic recommendations. Despite the progress in the understanding of this benign syndrome, a wide variation in physician evaluation and management persists. However, there is recent evidence that pediatricians are becoming more selective in admitting and investigating children with febrile seizures. Admitted children frequently had complex seizures, status epilepticus, or were ill looking. Considering the full scope of febrile seizures, the yield of investigations that might alter management remains low and does not justify extensive work-up or prolonged hospitalization.
Related Concept Videos
Seizures l: Introduction
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Increased Body Temperature
Seizures ll: Types
Encephalitis l: Introduction

