Related Experiment Video

Updated: May 14, 2026

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
14:25

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Published on: May 13, 2022

Oxidative stress and neurodegenerative disease

Laila Y Al-Ayadhi1

  • 1Department of Physiology, Faculty of Medicine, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 (1) 4672567/4786798. Fax. +966 (1) 4786798.

Neurosciences (Riyadh, Saudi Arabia)
|February 5, 2013
PubMed

Insights

Oxidative stress from free radicals contributes to neurodegenerative diseases. Antioxidant therapies may help manage conditions like Alzheimer's and Parkinson's, but require personalized approaches due to complex biochemistry.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Oxygen free radical formation is implicated in various neurodegenerative disorders.
  • Antioxidant therapy is a potential strategy to mitigate neurological disease progression.
  • Individualized treatment is crucial due to the complex nature of oxidative stress in disease.

Purpose of the Study:

  • To review the role of oxidative stress in neurodegenerative diseases.
  • To discuss the therapeutic potential of antioxidants for neurological disorders.
  • To highlight the need for tailored antioxidant strategies.

Main Methods:

  • Literature review of studies on oxidative stress and neurodegenerative diseases.
  • Analysis of antioxidant mechanisms and therapeutic efficacy.
  • Synthesis of information on Alzheimer disease, Parkinson disease, and multiple sclerosis.

Main Results:

  • Oxidative stress is a significant factor in the pathophysiology of neurodegenerative conditions.
  • Antioxidants show promise in preventing or delaying disease progression.
  • Current understanding of oxidative biochemistry necessitates personalized therapeutic interventions.

Conclusions:

  • Oxidative stress plays a critical role in neurodegenerative disorders such as Alzheimer disease, Parkinson disease, and multiple sclerosis.
  • Antioxidant therapies offer a potential avenue for managing these conditions.
  • Further research is needed to optimize individualized antioxidant treatment strategies.

More Related Videos

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...