Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition.

J M Barnes1, N M Barnes, B Costall

  • 1Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, U.K.

Brain Research
|January 22, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical Challenges in Clinical Research During the COVID-19 Pandemic.

Journal of bioethical inquiry·2020
Same author

Capture-recapture to estimate completeness of tuberculosis surveillance in two communities in South Africa.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2011
Same author

Accuracy and completeness of recording of confirmed tuberculosis in two South African communities.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2011
Same author

Traumatic oedema of larynx.

British dental journal·2010
Same author

Behavioural characterization of neuroleptic properties in the rodent.

Proceedings of the Royal Society of Medicine·2010
Same author

The Rationale of Complete Immobilization in Treatment of Infected Wounds.

British medical journal·2010

Angiotensin II inhibits acetylcholine release in the human brain. This effect is blocked by a specific antagonist, suggesting angiotensin II receptors are involved in regulating neurotransmitter release.

Area of Science:

  • Neuroscience
  • Neurochemistry
  • Pharmacology

Background:

  • The human temporal cortex plays a crucial role in cognitive functions.
  • Acetylcholine is a key neurotransmitter involved in memory and learning.
  • Angiotensin II is a peptide hormone with known functions in the cardiovascular and nervous systems.

Purpose of the Study:

  • To investigate the effect of Angiotensin II on acetylcholine release in the human temporal cortex.
  • To identify the presence and potential role of Angiotensin II receptors in this brain region.

Main Methods:

  • Biochemical analysis of [3H]acetylcholine release from human temporal cortex slices.
  • Use of a specific Angiotensin II receptor antagonist ([1-sarcosine, 8-threonine]-angiotensin II).
  • Binding assays using [125I]angiotensin II to identify receptor sites.

Related Experiment Videos

Main Results:

  • Angiotensin II significantly inhibited potassium-stimulated [3H]acetylcholine release.
  • The inhibitory effect of Angiotensin II was reversed by the specific antagonist.
  • High-affinity Angiotensin II binding sites were detected in the human temporal cortex.

Conclusions:

  • Angiotensin II modulates acetylcholine release in the human temporal cortex.
  • The findings suggest the presence and functional relevance of Angiotensin II receptors in regulating cholinergic neurotransmission in the human brain.