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Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition
J M Barnes1, N M Barnes, B Costall
1Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, U.K.
Brain Research
|January 22, 1990
Abstract:
Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.