Related Experiment Video
Updated: May 14, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
TNF-β +252 A>G polymorphism and susceptibility to cancer
Lin Yang1, Rennan Feng, Guiyou Liu
1Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, 23 Youzheng St., Nangang District, Harbin 150001, People's Republic of China.
The Tumor necrosis factor-β (TNF-β) +252 A>G polymorphism is linked to increased cancer risk. This meta-analysis confirms a positive association between this genetic variant and cancer susceptibility across various populations.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Tumor necrosis factor-β (TNF-β) is implicated in cancer development.
- The TNF-β +252 A>G polymorphism has been studied for its association with various cancers.
- Previous findings on this polymorphism's link to cancer susceptibility are inconsistent.
Purpose of the Study:
- To conduct a meta-analysis to determine the relationship between the TNF-β +252 A>G polymorphism and cancer risk.
- To clarify the controversial association between this genetic variant and cancer susceptibility.
Main Methods:
- Systematic electronic database searches were performed up to October 2011.
- Meta-analysis utilized random-effect models to calculate Odds Ratios (ORs) and 95% Confidence Intervals (CIs).
- Included 33 studies with 14,435 cancer patients and 10,583 healthy controls.
Main Results:
- A statistically significant association was found between the TNF-β +252 A>G polymorphism and overall cancer risk.
- Significant associations were observed in Asian, Caucasian, and other ethnic populations.
- Specific comparisons like GG vs. AA and G vs. A showed increased cancer risk (e.g., OR=1.43 for GG vs. AA).
Conclusions:
- The TNF-β +252 A>G polymorphism is positively associated with increased susceptibility to cancer.
- Further research is recommended to validate these associations for specific cancer types.
More Related Videos
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
TGF - β Signaling Pathway
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

