The current status of vertebrate cellular mRNA IRESs

Richard J Jackson1

  • 1Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom. rjj@mole.bio.cam.ac.uk

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Regulated mRNA Transport02:22

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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The technique helps...
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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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