Related Experiment Video
Updated: May 14, 2026

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
Published on: September 16, 2022
Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans
Vijay D Wagh1, Onkar J Deshmukh
1Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Maharashtra, Shirpur 425405, India.
Abstract:
Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesicle size, entrapment efficiency, and drug release were markedly dependent on surfactant : cholesterol ratio and quantity of ethanol used. Permeation of the drug through the skin was affected by cholesterol content in formulation. Itraconazole niosome were having larger zone of inhibition than marketed formulation when activity was checked against C. albicans. Niosomes may be a promising carrier for topical delivery of Itraconazole especially due to their simple production.
Related Concept Videos
Antifungal Agents
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Intrauterine Drug Delivery Systems
Oral Drug Delivery Systems: Continuous-Release Systems
Oral Drug Delivery Systems: Introduction
Oral Drug Delivery Systems: Delayed-Release Systems

