[Early diagnosis of nephrosclerosis in children with vesicoureteral reflux]

Comparison of results of standard complex of survey with changes of urine levels of biological inflammatory marker (MCP-1), marker of fibrogenesis (TGF-beta1), marker of angiogenesis (VEGF), markers of nephron damage (collagen IV, alpha-GST, pi-GST) in 140 children with vesicoureteral reflux before and 6 months after treatment was performed. It was found that nephrosclerotic process occurs even at low degrees of vesicoureteral reflux. Even in the absence of structural and functional disorders of the kidneys according to traditional methods of evaluation, there were significant changes in the levels of biological markers of inflammation, fibrosis, and angiogenesis, as well as damage of main elements of the nephron. The method for calculating the "index of early renal damage" is proposed; method allows to monitor the state of the renal parenchyma of children with this disease.