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Verrucous hemangioma expresses primitive markers.

Emma L Laing¹, Helen D Brasch, Ryan Steel

¹Gillies McIndoe Research Institute, Wellington, New Zealand.

Journal of Cutaneous Pathology

|February 6, 2013

Summary

Verrucous hemangioma (VH) shares primitive vascular markers with infantile hemangioma but lacks the embryonic marker HBZ. This difference suggests a distinct cellular origin for VH, with HBZ potentially distinguishing between the two conditions.

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Area of Science:

Vascular Biology
Developmental Biology
Dermatopathology

Background:

Verrucous hemangioma (VH) is a vascular malformation with histopathologic similarities to infantile hemangioma.
Characterizing the cellular makeup of VH is crucial for understanding its origin and differentiation.

Purpose of the Study:

To investigate the cellular phenotype of verrucous hemangioma.
To compare the expression of specific markers in VH and infantile hemangioma to elucidate their cellular origins.

Main Methods:

Immunohistochemistry was performed on paraffin-embedded VH tissue sections.
Expression of markers including SMA, CD34, Glut-1, D2-40, brachyury, ACE, Oct-4, HBZ, WT-1, and CD45 was analyzed.

Main Results:

VH endothelium expressed primitive markers (Oct-4, brachyury, ACE) and focal Glut-1, but lacked D2-40.
WT-1 was expressed in the pericyte layer of both VH and infantile hemangioma.
The embryonic marker HBZ was absent in VH but present in infantile hemangioma; CD45 was found in the interstitium.

Conclusions:

VH exhibits a primitive microvascular phenotype, sharing markers with infantile hemangioma.
The absence of HBZ in VH suggests a different cellular origin compared to infantile hemangioma.
HBZ expression can potentially differentiate between verrucous hemangioma and infantile hemangioma.