Related Experiment Video
Updated: Jan 24, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Effect of early measles vaccination (AIK-C strain) for preterm infants
Tomonori Ichikawa1, Atsutoshi Tsuji, Motoko Fujino
1Department of Pediatrics, Saitama Municipal Hospital Mother and Child Medical Center, Saitama, Japan.
Background:
The level of maternal antibodies decreases more quickly in preterm than term infants, leaving them unprotected against measles. To protect premature infants from measles, an early vaccination trial was investigated.
Methods:
Changes in the serum measles neutralization test (NT) antibody titer were examined in 152 infants (average gestational period, 29 weeks; average birthweight, 1203 g).
Results:
The average antibody titer (2(n)) was 2(3.5) at birth and 2(2.2) at 1-3 months of age, and in all cases, NT antibody titer decreased to <1:4 (150 IU/mL). The AIK-C measles vaccine was given to 17 preterm infants at the age of 6 months, and induced sufficient serological responses without any serious adverse events. NT antibody level did not decay during 12 months after vaccination.
Conclusion:
Early immunization at 6 months of age is effective to protect preterm infants in the outbreak setting.
More Related Videos
Related Concept Videos
Drug Dosing: Infants and Children
Vaccinations
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Thermal Strain
Shearing Strain
Measurements of Strain

