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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...

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Related Experiment Video

Updated: May 14, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Eccrine carcinoma : a rare cutaneous neoplasm.

Karima Idrissi Serhrouchni1, Taoufiq Harmouch, Laila Chbani

  • 1Department of Pathology, Hassan II University Hospital, Fez, 30000, Morocco. idrissisehrouchni@yahoo.fr

Diagnostic Pathology
|February 6, 2013
PubMed
Summary

Eccrine carcinoma, a rare skin cancer, typically affects the lower extremities in older adults. This case highlights a recurring eccrine carcinoma in a younger female, emphasizing the need for vigilance.

Related Experiment Videos

Last Updated: May 14, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Eccrine carcinoma is an exceptionally rare skin malignancy.
  • It predominantly affects the lower extremities in individuals during their sixth and seventh decades of life.
  • Cases are infrequently documented in medical literature.

Observation:

  • A 46-year-old female presented with a recurring exophytic tumor on her right lower extremity.
  • The tumor exhibited no local extension.
  • The initial lesion was surgically removed and diagnosed as eccrine carcinoma via biopsy.

Findings:

  • The case details a histopathologically confirmed eccrine carcinoma.
  • The patient's age (46 years) is atypical for the common demographic of this cancer.
  • The tumor's recurrence on the lower extremity was noted.

Implications:

  • This case expands the known clinical spectrum of eccrine carcinoma.
  • It underscores the importance of considering eccrine carcinoma in younger patients presenting with lower extremity tumors.
  • Further research may elucidate potential unique biological or clinical features in atypical presentations.