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Updated: May 14, 2026
Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart
Published on: September 28, 2016
Comparison of carbohydrate and lipid oxidation during continuous and intermittent exercise in patients with chronic
Mathieu Gayda1, Eve Normandin, Philippe Meyer
1Cardiovascular Rehabilitation and Prevention Centre (ÉPIC), Montreal Heart Institute and Université de Montréal, Montreal, Québec, Canad. mathieu.gayda@icm-mhi.org
Abstract:
Skeletal muscle substrate oxidation was compared during moderate-intensity continuous exercise (MICE) and high-intensity intermittent exercise (HIIE) in patients with heart failure and reduced ejection fraction (HFREF). Eighteen patients (aged 60 ± 9 years; LVEF, 26 ± 7%) randomly performed MICE (22 minutes at 60% of peak power) and HIIE (30 seconds at 100% of peak power interspersed by 30 seconds' rest for 16 minutes). Carbohydrate and lipid oxidation calculated using the Frayn equation were 4.8- and 1.42-fold higher during MICE and 5- and 1.22-fold higher during HIIE (P < 0.0001). HIIE and MICE can similarly and favourably increase carbohydrate and lipid oxidation in patients with HFREF.
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