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Related Concept Videos

Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
Types of Hormones01:21

Types of Hormones

Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell

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Effect of estetrol administration on brain and serum allopregnanolone in intact and ovariectomized rats.

The Journal of steroid biochemistry and molecular biology·2014
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Efficacy of a topical cosmetic slimming treatment for postmenopausal women: a randomized, double-blind, placebo controlled trial.

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Evaluation of brain-derived neurotrophic factor in menstrual blood and its identification in human endometrium.

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Ovarian follicular fluid contains immunoreactive estriol: lack of correlation with estradiol concentrations.

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Dose-response efficacy of a new estradiol transdermal matrix patch for 7-day application: a randomized, double-blind, placebo-controlled study. Italian Menopause Research Group.

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Related Experiment Video

Updated: May 14, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

Steroid hormones and BDNF.

N Pluchino1, M Russo, A N Santoro

  • 1Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy.

Neuroscience
|February 6, 2013
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) impacts brain plasticity and cognitive function. This review explores how hormones like estrogen and cortisol influence BDNF levels, offering clinical insights.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychiatry

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for synaptic plasticity, learning, and memory.
  • Altered BDNF levels are linked to neurodegenerative diseases (Alzheimer's, Parkinson's) and mood disorders (depression, schizophrenia).
  • Plasma BDNF serves as a biomarker for cognitive function, particularly in aging women.

Purpose of the Study:

  • To review the correlation between BDNF and gonadal/adrenal hormones.
  • To explore the relationship between BDNF, hormones, and gender differences in mental health.
  • To highlight potential clinical applications of understanding BDNF-hormone interactions.

Main Methods:

  • Literature review of studies investigating BDNF and hormone levels.
  • Analysis of research on neurotrophins, gonadal steroids (estrogen, progesterone, testosterone), and adrenal hormones (cortisol, DHEA).
  • Synthesis of findings related to cognitive function, aging, and mental disorders.

Main Results:

  • Evidence suggests a co-regulation between BDNF and gonadal/adrenal hormones.
  • Hormonal influences on BDNF may contribute to gender-specific differences in mental health incidence.
  • BDNF and hormone levels are implicated in cognitive deficits and aging processes.

Conclusions:

  • BDNF and gonadal/adrenal hormones interact, influencing brain function and mental health.
  • Understanding these interactions is vital for addressing cognitive decline and gender disparities in psychiatric conditions.
  • Further research can lead to novel therapeutic strategies targeting BDNF-hormone pathways.