Concurrent Takayasu arteritis with common variable immunodeficiency and moyamoya disease

Area of Science:

• Immunology
• Neurology
• Rheumatology

Background:

• Takayasu arteritis is a rare large vessel vasculitis affecting the aorta and its branches.
• Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by antibody deficiency and recurrent infections.

Observation:

• A young male patient with a history of CVID presented with multiple cerebrovascular accidents.
• This presentation suggests a possible link between CVID and the development or exacerbation of Takayasu arteritis.

Findings:

• The case highlights a unique co-occurrence of possible Takayasu arteritis, CVID, and moyamoya disease.
• Cerebrovascular accidents were the primary clinical manifestation in this patient.

Implications:

• This case underscores the importance of considering autoimmune and inflammatory conditions in patients with CVID presenting with neurological events.
• Further research into the interplay between immunodeficiency and vasculitis may reveal novel therapeutic targets for Takayasu arteritis.