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Updated: May 14, 2026

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
Published on: April 12, 2011
Objective evaluation of muscle strength in infants with hypotonia and muscle weakness
Linda Reus1, Leo A van Vlimmeren, J Bart Staal
1Radboud University Nijmegen Medical Centre, Department of Rehabilitation, Pediatric Physical Therapy, Nijmegen, The Netherlands. l.reus@reval.umcn.nl
Insights
Objective infant muscle strength measurement is now possible. This study provides reference values and confirms significantly decreased muscle strength in infants with Prader-Willi Syndrome (PWS), correlating with motor delay.
Area of Science:
- Pediatric Neurology
- Developmental Pediatrics
- Clinical Measurement
Background:
- Objective muscle strength assessment is crucial for evaluating infants with motor delay, hypotonia, or weakness.
- Lack of standardized measurement methods and reference values hinders accurate clinical assessment in infants.
Purpose of the Study:
- To develop and validate a reliable method for objectively measuring muscle strength in infants.
- To establish normal reference values for infant muscle strength.
- To assess muscle strength in infants with Prader-Willi Syndrome (PWS) and its correlation with motor development.
Main Methods:
- A novel method for measuring infant muscle strength was developed and tested.
- 81 typically developing infants (6-36 months) and 17 infants with PWS (24 months) participated.
- Inter-rater reliability and convergent validity (correlation with age, height, weight) were assessed.
Main Results:
- The measurement method demonstrated good inter-rater reliability (ICC=.84) and strong convergent validity (r=.79-.85).
- A regression model predicted 73% of muscle strength variance based on age, height, and weight.
- Infants with PWS exhibited significantly reduced muscle strength, with greater weakness correlating with more severe motor delay (r=.75).
Conclusions:
- A reliable and valid method for objective infant muscle strength measurement has been established.
- This method provides essential reference data for clinical evaluation.
- Significantly decreased muscle strength and its association with motor delay in infants with PWS were confirmed.
Abstract:
The clinical evaluation of an infant with motor delay, muscle weakness, and/or hypotonia would improve considerably if muscle strength could be measured objectively and normal reference values were available. The authors developed a method to measure muscle strength in infants and tested 81 typically developing infants, 6-36 months of age, and 17 infants with Prader-Willi Syndrome (PWS) aged 24 months. The inter-rater reliability of the measurement method was good (ICC=.84) and the convergent validity was confirmed by high Pearson's correlations between muscle strength, age, height, and weight (r=.79-.85). A multiple linear regression model was developed to predict muscle strength based on age, height, and weight, explaining 73% of the variance in muscle strength. In infants with PWS, muscle strength was significantly decreased. Pearson's correlations showed that infants with PWS in which muscle strength was more severely affected also had a larger motor developmental delay (r=.75).
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