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Updated: May 14, 2026

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
Published on: March 7, 2018
Antibody therapeutics targeting ion channels: are we there yet?
1Department of Neuroscience, High Throughput Biology Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Abstract:
The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.
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