Related Experiment Video
Updated: May 14, 2026

4D Printed Bifurcated Stents with Kirigami-Inspired Structures
Published on: July 25, 2019
Do angle and anatomy influence outcomes in bifurcation stenting?
L Lucisano1, M Pennacchi, R E Stio
1Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, Policlinico Umberto I, "La Sapienza" University of Rome, Rome, Italy.
Insights
Coronary bifurcation lesions are complex, with the distal angle (B) uniquely predicting outcomes. Understanding bifurcation anatomy is crucial for successful treatment strategies.
Area of Science:
- Interventional Cardiology
- Cardiovascular Anatomy
- Medical Device Innovation
Background:
- Coronary bifurcation lesions present significant treatment challenges.
- Current treatment strategies lack consensus due to anatomical variations and disease complexity.
- Key anatomical features like takeoff angle (A) and carina angle (B) influence outcomes.
Purpose of the Study:
- To highlight the importance of bifurcation angle and anatomy in treatment outcomes.
- To identify critical anatomical predictors for successful intervention.
- To explore the potential of novel dedicated devices for bifurcation lesions.
Main Methods:
- Analysis of anatomical factors, including proximal (A) and distal (B) angles.
- Evaluation of disease extent and side branch size.
- Consideration of anatomical changes post-wiring and pre-dilatation.
Main Results:
- The distal angle (B) was identified as a unique, statistically significant predictor of outcomes.
- Bifurcation angle and anatomy are critical for both short- and long-term results.
- Anatomical assessment should occur after key procedural steps due to potential variations.
Conclusions:
- Distal angle (B) is a key factor influencing coronary bifurcation lesion treatment success.
- Comprehensive evaluation of bifurcation anatomy is essential for optimal patient outcomes.
- Further research into dedicated bifurcation devices may offer improved treatment solutions.
Abstract:
Coronary bifurcation lesions are regarded as complex and their treatment is still the subject of substantial debate. Important elements to consider before approaching a bifurcation include angle and anatomy, in particular the take off angle (proximal angle, A) that is between the proximal MB and SB and the carina angle (distal angle, B) that is between distal main branch (MB) and side branch (SB) and also the extent and distribution of disease on the side branch and its size. Many techniques have been used to treat coronary bifurcation lesions such as provisional stenting or double stenting but no consensus technique has been accepted primarily due to variation of disease severity, angle and anatomy. Angle B is the unique statistically significant independent predictor factor influencing outcomes. Bifurcation angle and anatomy are important predictors of short and long-term outcomes after bifurcation treatment. Moreover we should evaluate it after wiring MB and SB so as after pre-dilatation because of side branch access and carina area angle anatomy variation and plaque shift. Should be investigated if the developing of new dedicated devices for bifurcation lesions could mix the advantages of one and two-stent techniques.