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[Toxic epidermal necrolysis associated with acute infection by Mycoplasma pneumoniae]

Roberta Amelia Calvano1, María Florencia Scacchi, Magdalena María Sojo

  • 1Sección Dermatología Pediátrica, Servicio de Pediatría, Hospital Italiano de Buenos Aires. Roberta.calvano@hospitalitaliano.org.ar

Archivos Argentinos De Pediatria
|February 6, 2013
PubMed

Insights

Toxic epidermal necrolysis, a severe drug reaction, can be linked to Mycoplasma pneumoniae infections. This case highlights a pediatric patient successfully treated for this severe cutaneous reaction.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pediatrics

Background:

  • Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis are severe cutaneous reactions.
  • These reactions are often idiosyncratic, triggered by drugs or infections like Mycoplasma pneumoniae.

Observation:

  • A 5-year-old female presented with fever and a generalized rash involving mucous membranes.
  • The patient was diagnosed with toxic epidermal necrolysis associated with Mycoplasma pneumoniae infection.

Findings:

  • Positive IgM serology confirmed Mycoplasma pneumoniae infection.
  • Initial biopsy findings were consistent with erythema multiforme major.

Implications:

  • This case underscores Mycoplasma pneumoniae as a potential trigger for severe cutaneous adverse reactions.
  • Multimodal treatment including corticosteroids, IVIG, and plasmapheresis can be effective.
  • Prompt diagnosis and management are crucial for preventing complications in pediatric patients.

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