[Protein C deficiency in patient with sepsis-associated disseminated intravascular coagulation and deep vein...

Area of Science:

• Hematology
• Pediatric critical care
• Pathophysiology

Background:

• Disseminated intravascular coagulation (DIC) is a serious condition characterized by abnormal activation of coagulation, leading to microvascular thrombosis and consumption of clotting factors and platelets.
• Sepsis is a primary driver of DIC in pediatric populations, presenting with diverse clinical manifestations including bleeding, purpura, and gangrene.
• Deep venous thrombosis (DVT) can be a complication of DIC, highlighting the complex interplay of prothrombotic and consumptive processes.

Observation:

• A pediatric patient presented with clinical signs of sepsis-associated DIC.
• Concurrent deep venous thrombosis was identified in the affected patient.
• Diagnostic workup revealed an underlying inherited thrombophilia, specifically protein C deficiency.

Findings:

• The patient's sepsis-associated DIC was complicated by deep venous thrombosis.
• Protein C deficiency was identified as a significant inherited thrombophilic factor.
• This case underscores the potential for coexisting thrombotic and consumptive coagulopathies in sepsis.

Implications:

• Early recognition of inherited thrombophilia is crucial in pediatric patients with sepsis-induced DIC and thrombosis.
• Understanding the genetic predisposition to thrombosis can guide management strategies for DIC.
• This case highlights the importance of comprehensive diagnostic evaluation in complex pediatric coagulation disorders.