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Updated: May 14, 2026

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
Published on: February 19, 2020
Nav 1.4 slow-inactivation: is it a player in the warm-up phenomenon of myotonic disorders?
1Department of Neurology, University of California Davis School of Medicine, 4635 Second Avenue, Room 1004A, Sacramento, California 95817, USA.
Abstract:
Myotonia is a heritable disorder in which patients are unable to willfully relax their muscles. The physiological basis for myotonia lies in well-established deficiencies of skeletal muscle chloride and sodium conductances. What is unclear is how normal muscle function can temporarily return with repeated movement, the so-called "warm-up" phenomenon. Electrophysiological analyses of the skeletal muscle voltage-gated sodium channel Nav 1.4 (gene name SCN4A), a key player in myotonia, have revealed several parallels between the Nav 1.4 biophysical signature, specifically slow-inactivation, and myotonic warm-up, which suggest that Nav 1.4 is critical not only in producing the myotonic reaction, but also in mediating the warm-up.
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