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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Immune thrombocytopenic purpura in a child with thyroid hormone resistance - a rare presentation
Sumantra Sarkar1, Rakesh Mondal, Madhumita Nandi
1Department of Pediatric Medicine, SSKM Hospital, Kolkata, West Bengal, India. sumantra.com@gmail.com
Abstract:
Resistance to thyroid hormone (RTH) is a rare entity characterized by a decreased target tissue responsiveness of thyroid hormones. Although immune thrombocytopenic purpura (ITP) has been reported with different thyroid disorders in the literature, its coexistence with RTH is not known. A 9-year-old girl presented with ITP and features of hypothyroidism in the form of goiter and growth retardation. She was subsequently found to have RTH. High-dose thyroid hormone replacement was required to overcome the resistance that not only ameliorated the features of hypothyroidism but also brought an apparent remission of ITP.
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