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Updated: May 14, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Hodgkin lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma
John R Krause1, Lee C Drinkard, Latoya C Keglovits
1Section of Hematopathology. Department of Pathology, Baylor University Medical Center at Dallas, Dallas, Texas (Krause, Keglovits); and Metroplex Cancer Specialists, Keller, Texas (Drinkard).
Abstract:
Transformation to a large cell lymphoma may occur during the course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in approximately 5% of the cases. This is known as Richter's transformation. A much less frequent transformation to Hodgkin lymphoma may occur. We report a case of CLL/SLL in which a transformation to Hodgkin lymphoma occurred, and we review previously published reports of this transformation. Transformation to Hodgkin lymphoma in CLL/SLL has a poor outcome compared to de novo cases of Hodgkin lymphoma.
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