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Sulphamethoxazole acetylation in fast and slow acetylators
A Bozkurt1, N E Basci, A Isimer
1Department of Pharmacology, University of Hacettepe, Ankara, Turkey.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|April 1, 1990
Abstract:
Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.