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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Updated: May 14, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Non-IBD colitides (eosinophilic, microscopic).

Eugene F Yen1, Darrell S Pardi

  • 1Division of Gastroenterology, University of Chicago, Pritzker School of Medicine, NorthShore University HealthSystem, Evanston, IL, USA. eyen@uchicago.edu

Best Practice & Research. Clinical Gastroenterology
|February 7, 2013
PubMed
Summary
This summary is machine-generated.

Microscopic colitis, including lymphocytic and collagenous types, is a frequent cause of chronic diarrhea in older adults. Its incidence is rising, nearing levels seen in inflammatory bowel disease.

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Area of Science:

  • Gastroenterology
  • Colorectal Diseases
  • Inflammatory Bowel Disease

Background:

  • Microscopic colitis, encompassing lymphocytic colitis and collagenous colitis, is a significant cause of chronic diarrhea, particularly in older populations.
  • The incidence of microscopic colitis has notably increased, now comparable to other forms of inflammatory bowel disease.
  • Eosinophilic colitis is a rare gastrointestinal disorder with limited available data.

Purpose of the Study:

  • To provide an updated review of the epidemiology, diagnosis, and treatment of microscopic colitis.
  • To highlight the increasing incidence and clinical significance of microscopic colitis.
  • To address the limited data on eosinophilic colitis and emphasize the importance of excluding secondary causes.

Main Methods:

  • Literature review and synthesis of current data on microscopic colitis.
  • Analysis of epidemiological trends, diagnostic approaches, and therapeutic strategies.
  • Review of existing studies on eosinophilic colitis and colonic eosinophilia.

Main Results:

  • Microscopic colitis is increasingly diagnosed and presents similarly to inflammatory bowel disease.
  • Epidemiological data indicates a rising incidence over time.
  • There is a scarcity of information regarding eosinophilic colitis.

Conclusions:

  • Microscopic colitis is a common and increasingly prevalent condition requiring updated understanding of its epidemiology, diagnosis, and treatment.
  • Further research is needed for eosinophilic colitis, with a focus on identifying secondary causes of colonic eosinophilia.