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Clinical phenomenology and mortality in Charles Bonnet syndrome

Maria I Lapid1, M Caroline Burton, Megan T Chang

  • 1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. lapid.maria@mayo.edu

Journal of Geriatric Psychiatry and Neurology
|February 7, 2013
PubMed

Insights

Charles Bonnet syndrome (CBS) patients often develop dementia, with high mortality linked to advanced age and kidney disease. Medical burden did not impact survival rates in this study.

Area of Science:

  • Neurology
  • Geriatrics
  • Ophthalmology

Background:

  • Charles Bonnet syndrome (CBS) presents with diverse clinical features despite diagnostic criteria.
  • Understanding the clinical course and mortality of CBS is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical course and mortality rates in patients diagnosed with Charles Bonnet syndrome (CBS).

Main Methods:

  • Retrospective chart review of 77 patients diagnosed with CBS.
  • Demographic data, clinical information, and medical burden scores were collected.
  • Kaplan-Meier survival analysis and Cox proportional hazard models were employed to assess mortality predictors and compare to general population rates.

Main Results:

  • 26% of CBS patients developed dementia, predominantly Lewy body dementia.
  • A significant mortality rate (60%) was observed, higher than the general population.
  • Older age (75-84 and >85 years) and renal disease were associated with increased mortality risk (HR 3.34 and 4.58, and HR 3.39 respectively).
  • Medical burden scores did not correlate with overall mortality.

Conclusions:

  • Charles Bonnet syndrome (CBS) is associated with a substantial risk of dementia development and elevated mortality.
  • Advanced age and co-existing renal disease are key predictors of mortality in CBS patients.
  • Medical burden is not a significant factor in the mortality of individuals with CBS.
Abstract

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