Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of high-altitude exposure on Torque Teno virus and immunosuppression levels in lung transplantation recipients: climbing Mount Jebel Toubkal.

Scientific reports·2026
Same author

Perioperative hemoglobin concentrations are associated with acute kidney injury after deceased donor liver transplantation.

Frontiers in medicine·2026
Same author

Glycocalyx Degradation in Pediatric Patients with Cyanotic and Acyanotic Congenital Heart Disease Undergoing Cardiac Repair Surgery.

Journal of clinical medicine·2026
Same author

The association of perioperative serum albumin concentrations with outcome after deceased donor liver transplantation.

BMC anesthesiology·2025
Same author

Effect of chronic lung allograft dysfunction phenotypes on the outcome after lung retransplantation: A retrospective single-center data analysis.

JTCVS open·2025
Same author

Incidence and outcomes of AKI in postoperative patients admitted to ICU using full KDIGO criteria - a cohort study.

Journal of clinical anesthesia·2023
Same journal

How to establish and run a national ICU benchmarking registry.

Current opinion in critical care·2026
Same journal

Cardiogenic shock - toward phenotype-directed, precision management.

Current opinion in critical care·2026
Same journal

The future of critical care nutrition: from calorie counting to precision personalized metabolism therapy.

Current opinion in critical care·2026
Same journal

Editorial introduction.

Current opinion in critical care·2026
Same journal

Generative artificial intelligence for outcome prediction in critical care: the future is now?

Current opinion in critical care·2026
Same journal

Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy.

Current opinion in critical care·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Extracorporeal liver support.

Peter Faybik1, Claus-Georg Krenn

  • 1Department of Anesthesiology, General Intensive Care and Pain Therapy, Medical University of Vienna, Vienna, Austria. peter.faybik@meduniwien.ac.at

Current Opinion in Critical Care
|February 7, 2013
PubMed
Summary
This summary is machine-generated.

Extracorporeal liver support systems aim to aid patients with liver failure awaiting transplantation. Current systems show limited long-term survival benefits, necessitating further development for improved patient outcomes.

More Related Videos

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse
05:30

Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse

Published on: March 9, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
09:29

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse
05:30

Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse

Published on: March 9, 2022

Area of Science:

  • Hepatology
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Liver failure mortality remains high despite medical advances.
  • Liver transplantation is the definitive treatment for many, but donor organs are scarce.
  • Extracorporeal liver support systems (ECLSS) aim to bridge patients to transplant or support liver regeneration.

Purpose of the Study:

  • To review prospective randomized trials of ECLSS with survival as the primary outcome.
  • To assess the efficacy of nonbiological (detoxification) and biological (detoxification, synthesis, metabolism) ECLSS.
  • To evaluate the impact of ECLSS on patient survival in liver failure.

Main Methods:

  • Focus on prospective randomized trials.
  • Analysis of studies with survival rate as the primary outcome parameter.
  • Inclusion of both nonbiological and biological extracorporeal liver support systems.

Main Results:

  • Some trials showed short-term benefits in acute-on-chronic liver failure patients.
  • No significant long-term survival improvement was observed with current ECLSS.
  • Data for acute liver failure patients are limited, precluding definitive conclusions.

Conclusions:

  • Future ECLSS may incorporate novel adsorbents and regional citrate anticoagulation.
  • Substitution of damaged albumin is a potential future development.
  • Continued research is needed to improve long-term outcomes for liver failure patients.