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Citalopram-associated gambling: a case report.

Ilaria Cuomo¹, Georgios D Kotzalidis, Federica Caccia

¹NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Unit of Psychiatry, School of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University, Via di Grottarossa 1035-1039, 00189, Rome, Italy, ilaria.cuomo@uniroma1.it.

Journal of Gambling Studies

|February 7, 2013

Summary

Selective serotonin reuptake inhibitors like citalopram may rarely induce pathological gambling. This case study explores a patient whose gambling emerged during citalopram treatment for depression and somatisation disorder.

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Area of Science:

Neuroscience
Psychiatry

Background:

Pathological gambling is a known side effect of dopaminergic drugs for Parkinson's disease.
It is rarely reported with selective serotonin reuptake inhibitors (SSRIs).

Observation:

A 58-year-old woman with somatisation disorder and major depression was treated with citalopram.
After 7 months, her mood symptoms improved, but she developed pathological gambling behavior.
Discontinuing citalopram reduced gambling, but did not improve other psychiatric symptoms.

Findings:

Citalopram, an SSRI, may induce pathological gambling, potentially through combined serotonergic and dopaminergic mechanisms.
The patient's gambling onset coincided with citalopram treatment, suggesting a link.
Mood destabilization from citalopram might have contributed to the gambling behavior.

Implications:

This case highlights a rare but significant side effect of citalopram.
Understanding the neurobiological interplay of SSRIs and gambling behavior is crucial.
Further research is needed to clarify the mechanisms linking SSRIs to pathological gambling.