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Related Experiment Video

Updated: May 14, 2026

Normothermic Ex Vivo Liver Machine Perfusion in Mouse
13:14

Normothermic Ex Vivo Liver Machine Perfusion in Mouse

Published on: September 25, 2023

Machine perfusion viability testing.

Tim C van Smaalen1, E R Pieter Hoogland, L W Ernest van Heurn

  • 1Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands. tim.van.smaalen@mumc.nl

Current Opinion in Organ Transplantation
|February 7, 2013
PubMed
Summary

Assessing kidney graft viability before transplant is crucial. Current hypothermic machine perfusion (HMP) markers and biomarkers lack predictive accuracy, necessitating new methods for reliable kidney transplant outcomes.

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Biomarker discovery

Background:

  • Pretransplant kidney graft viability assessment is vital for transplant decisions.
  • Increasing demand for donor kidneys and use of marginal organs heighten the need for viability markers.
  • Hypothermic machine perfusion (HMP) offers a platform for assessing donor kidney viability.

Purpose of the Study:

  • To review novel developments in kidney graft viability testing during HMP.
  • To discuss future prospects for improving pretransplant viability assessment.
  • To address the need for reliable markers to optimize transplant outcomes.

Main Methods:

  • Analysis of machine perfusion parameters during HMP.
  • Evaluation of perfusate biomarkers (e.g., LDH, AST, IL-18).

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Last Updated: May 14, 2026

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Normothermic Ex Vivo Liver Machine Perfusion in Mouse

Published on: September 25, 2023

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

  • Exploration of emerging techniques like contrast-enhanced ultrasound and MRI spectrometry.

    • Main Results:

    • Perfusion parameters and biomarkers correlate with transplant outcomes but lack predictive value.
    • Existing viability tests are not sufficiently reliable for clinical decision-making.
    • Novel imaging and perfusion techniques show promise but require further validation.

    Conclusions:

    • Current HMP characteristics and biomarkers are insufficient for predicting transplant outcomes.
    • There is a critical need for developing more reliable kidney graft viability assessment methods.
    • Future advancements in viability testing are essential for clinical utility and improved transplant success.