Related Experiment Video
Updated: May 14, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Cerebral hemodynamic changes in obstructive sleep apnea syndrome after continuous positive airway pressure treatment
Pedro Enrique Jiménez Caballero1, Ramón Coloma Navarro, Oscar Ayo Martín
1Department of Neurology, Hospital San Pedro de Alcántara, Avenida de Pablo Naranjo, 10003 Cáceres, Spain. pjimenez1010j@yahoo.es
Background:
Patients with obstructive sleep apnea syndrome (OSAS) are at increased risk for cerebrovascular diseases. The underlying mechanisms remain obscure. It may occur through a reduction in cerebral vascular reactivity. Continuous positive airway pressure (CPAP) is effective in reducing the occurrence of apneas. We hypothesized that treatment with CPAP improves cerebral vascular reactivity.
Methods:
This is a prospective study with OSAS patients. The apnea test (ApT) was calculated as an increase of mean artery velocity during apnea: [Artery velocity in apnea minus Resting artery velocity]/Resting artery velocity expressed as percentage. After 2 years of CPAP treatment, the test was repeated.
Results:
Seventy-six patients represented the study pool. After 2 years of treatment with CPAP, we were able to conduct a reassessment in 65 patients. Of the 65 patients who finished the clinical study, 56 were men, and 9 were women, with an average age of 48.1 ± 10.4 years. There was an improvement in the ApT after CPAP treatment (30.8 ± 12.1 vs 39.8 ± 15.1; p:0.000). The values of cerebral blood flow velocities, diastolic blood pressure in apnea, and basal heart rate decreased.
Conclusions:
Cerebral vascular reactivity in OSAS patients measured by ApT improved after 2 years of CPAP.
More Related Videos
07:54Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
11:26Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Increased Intracranial Pressure ll: Pathophysiology
Increased Intracranial Pressure l: Introduction
Hyperpnea and Hyperventilation