Related Experiment Video

Updated: May 14, 2026

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

[Erythema migrans]

Lenka Krbková1, Zuzana Náterová

  • 1Clinic of Pediatric Infectious Diseases, The University Hospital Brno, Czech Republic. lkrbkova@fnbrno.cz

Klinicka Mikrobiologie a Infekcni Lekarstvi
|February 7, 2013
PubMed

Insights

Erythema migrans (EM), a skin manifestation of Lyme borreliosis (LB), is detailed, including new Borrelia genospecies. This review covers EM

Area of Science:

  • Dermatology and Infectious Diseases
  • Microbiology and Vector-borne Diseases

Context:

  • Erythema migrans (EM) is the most frequent clinical presentation of Lyme borreliosis (LB).
  • Focus on the Czech Republic (CR) highlights regional epidemiology and diagnostics.
  • Emergence of new Borrelia genospecies (B. lusitaniae, B. spielmanii) necessitates updated understanding.

Purpose:

  • To provide a comprehensive overview of current knowledge on erythema migrans.
  • To detail the etiology, epidemiology, pathogenesis, clinical presentation, diagnosis, and therapy of EM.
  • To discuss differential diagnoses and therapeutic strategies for EM in the CR.

Summary:

  • Summarizes etiology, epidemiology, pathogenesis, clinical signs, diagnostics, and therapy of erythema migrans (EM).
  • Highlights new Borrelia genospecies (B. lusitaniae, B. spielmanii) and their presence in European ticks.
  • Compares EM clinical forms and differential diagnoses between Europe and the USA; discusses diagnostic methods and antibiotic choices.

Impact:

  • Enhances understanding of Lyme borreliosis diagnostics and treatment.
  • Provides clinicians with up-to-date information for managing erythema migrans.
  • Contributes to public health awareness regarding tick-borne diseases and their manifestations.

More Related Videos

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Related Concept Videos

Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Migration00:53

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...