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MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia
Zohreh Rahimi1, Ziba Rahimi, Maria Omidi Shahsavandi
1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. zrahimi@kums.ac.ir
Aim:
To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia.
Patients & Methods:
MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women.
Results:
A significantly higher frequency of MMP-9 CT genotype was observed in both mild and severe pre-eclamptic women compared with controls. In the presence of CT + TT genotype the risk of severe pre-eclampsia increased 2.37-fold (p = 0.02). In women with early-onset pre-eclampsia the frequency of MMP-9 CT + TT genotype was significantly higher (p = 0.045) compared with those with late-onset pre-eclampsia.
Conclusion:
The MMP-9 variant could be a useful biomarker of susceptibility to severe pre-eclampsia and early-onset severe pre-eclampsia.