Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Searching smarter, not harder: leveraging AI to enhance literature searches for theory-driven reviews-A methodological case study.

BMC medical research methodology·2026

Same author

Using a patient-reported history questionnaire to aid decision-making in the lung cancer diagnostic pathway: a single centre observational study of primary care chest X-ray referrals.

Clinical radiology·2025

Same author

Compatibility and combination of world <i>W</i>-boson mass measurements.

The European physical journal. C, Particles and fields·2024

Same author

Immune modulatory effects of tulathromycin, gamithromycin, and oxytetracycline in cattle.

BMC veterinary research·2024

Same author

Premature Deaths Due To Heat Exposure: The Potential Effects of Neighborhood-Level Versus City-Level Acclimatization Within US Cities.

GeoHealth·2024

Same author

Next step in the development of mesoprogestins: the preclinical profile of EC313.

Frontiers in endocrinology·2023

Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026

Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026

Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026

Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026

Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026

Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 14, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

2D∕3D registration algorithm for lung brachytherapy.

P S Zvonarev¹, T J Farrell, R Hunter

¹McMaster University, Medical Physics and Applied Radiation Sciences, Hamilton, Ontario, Canada. zvonarp@mcmaster.ca

Medical Physics

|February 8, 2013

Summary

This summary is machine-generated.

A new algorithm accurately registers 2D X-ray images with 3D CT scans for lung brachytherapy. This 2D/3D registration method achieves clinically acceptable accuracy, aiding high dose rate (HDR) treatments.

More Related Videos

Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

Published on: October 13, 2023

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Related Experiment Videos

Last Updated: May 14, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

Published on: October 13, 2023

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Area of Science:

Medical Imaging
Radiotherapy Physics

Background:

Accurate image registration is crucial for effective lung brachytherapy.
High dose rate (HDR) brachytherapy requires precise targeting of tumors.

Purpose of the Study:

To develop and validate a 2D/3D registration algorithm for aligning orthogonal X-ray images with CT volumes in HDR lung brachytherapy.

Main Methods:

A rigid registration model using pixel/voxel intensity matching.
A novel similarity measure combining normalized mutual information, image gradient, and intensity difference.
Validation using simple body and anthropomorphic phantoms with simulated treatment features.

Main Results:

Mean registration errors of 2.2 mm (simple phantom) and 1.9 mm (anthropomorphic phantom).
Errors were comparable to interoperator catheter digitization error (1.6 mm).
Preliminary patient data showed a mean registration error of 4.2 mm.

Conclusions:

The proposed 2D/3D registration algorithm provides clinically acceptable accuracy for lung HDR brachytherapy.
The method is robust to initial misregistration and foreign objects.
Results are promising despite imaging challenges during treatment.