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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Updated: May 14, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Morphological and functional differences between normal-tension and high-tension glaucoma.

Janek Häntzschel1, Naim Terai, Friederike Sorgenfrei

  • 1Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany. janek.haentzschel@uniklinikumdresden.de

Acta Ophthalmologica
|February 8, 2013
PubMed
Summary

Normal-tension glaucoma (NTG) patients show less visual field damage and better nerve fibre layer preservation than high-tension glaucoma (HTG) patients, even with similar optic nerve head damage. This suggests NTG may have a slower progression rate.

Keywords:
HRThigh-tension glaucomanormal-tension glaucomaoptic nerve headvisual field

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Neuropathy

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) are distinct subtypes.
  • Comparing these subtypes at equivalent structural damage levels is crucial for understanding disease progression.

Purpose of the Study:

  • To compare visual field (VF) and nerve fibre layer (NFL) loss in NTG versus HTG patients.
  • To assess these differences at a matched level of optic nerve head (ONH) structural damage.

Main Methods:

  • A retrospective, pair-matched study of 126 eyes with NTG and 126 eyes with HTG.
  • Optic nerve head damage was matched using Heidelberg Retina Tomograph (HRT III) measurements (rim volume, area, disc size).
  • Visual field (Humphrey perimetry) and nerve fibre layer thickness (GDxVCC) were compared.

Main Results:

  • Comparable structural ONH damage was confirmed between NTG and HTG groups.
  • NTG eyes exhibited significantly less visual field damage (MD, PSD) than HTG eyes.
  • Nerve fibre layer thickness was greater in NTG patients compared to HTG patients, particularly in the superior and inferior sectors.

Conclusions:

  • At equivalent ONH structural damage, NTG patients demonstrate less visual field impairment.
  • NTG patients appear to have better-preserved nerve fibre layers compared to HTG patients.
  • These findings suggest potential differences in disease mechanisms or progression between NTG and HTG.