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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance.

Ruth Ann Marrie¹, John D Fisk, Bo Nancy Yu

¹Department of Internal Medicine, University of Manitoba, Winnipeg, Canada. rmarrie@hsc.mb.ca

|February 8, 2013

Summary

Administrative data can reliably track mental health conditions in multiple sclerosis (MS). People with MS have higher rates of depression, anxiety, and bipolar disorder compared to the general population.

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Area of Science:

Neurology
Psychiatry
Public Health

Background:

Mental comorbidity is common in multiple sclerosis (MS) but its impact is not well-defined.
Methods are needed to support research on mental comorbidity in MS.
This study validated administrative case definitions for mental comorbidities in MS.

Purpose of the Study:

To validate administrative case definitions for mental comorbidities in MS.
To estimate the prevalence of mental comorbidities in MS and compare it to the general population.

Main Methods:

Used administrative health data to identify individuals with MS and a matched general population cohort.
Developed and validated administrative case definitions for various mental comorbidities against medical records using kappa statistics.
Estimated the prevalence of mental comorbidities in both populations.

Main Results:

Administrative definitions showed moderate to near-perfect agreement with medical records for various mental comorbidities (kappa values ranging from 0.23 to 1.0).
Prevalence of depression, anxiety, and bipolar disorder was significantly higher in the MS population compared to the general population.
Schizophrenia prevalence was similar between MS and general populations.

Conclusions:

Administrative data provide a valid method for monitoring mental comorbidity in MS.
Mental comorbidities, excluding schizophrenia, are more prevalent in individuals with MS than in the general population.