Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interspecies extrapolation of pharmacokinetics.

C C Travis1, R K White, R C Ward

  • 1Health and Safety Research Division, Computing and Telecommunications Division Oak Ridge National Laboratory, TN 37831-6109.

Journal of Theoretical Biology
|February 9, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial.

Annals of surgical oncology·2026
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

Fine structure of swarmers of Cladophora and Chaetomorpha : III. Wall synthesis and development.

Planta·2014
Same author

The death crisis and pastoral counseling.

Journal of religion and health·2013
Same author

Cancer risk management A review of 132 federal regulatory decisions.

Environmental science & technology·2012
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

This study demonstrates that toxic response depends on physiological time. For metabolically deactivated toxins, the scaling law is mg kg-1 per physiological time unit (pt-1), approximating mg kg-0.75 day-1 at low doses.

Area of Science:

  • Pharmacokinetics and toxicological scaling
  • Physiologically based pharmacokinetic (PBPK) modeling

Background:

  • Toxicological response is often linked to the concentration of a toxic substance over time.
  • Interspecies scaling of toxicological data is crucial for risk assessment.

Purpose of the Study:

  • To demonstrate the appropriate interspecies scaling law for toxic compounds.
  • To link toxic response to the time profile of toxicant concentration in target tissues within a physiological time framework.

Main Methods:

  • Utilizing physiologically based pharmacokinetic (PBPK) models.
  • Analyzing the time profile of toxic moiety concentration in target tissues.

Main Results:

  • For metabolically deactivated toxic compounds, the appropriate interspecies scaling law is mg kg-1 per unit of physiological time (mg kg-1 pt-1).

Related Experiment Videos

  • At low dose rates, this metric approximates mg kg-0.75 day-1.
  • For spontaneously deactivated reactive metabolites, an approximate interspecies scaling law is mg kg-1 day-1.

    • Conclusions:

    • Physiological time is a critical factor in interspecies toxicological scaling.
    • Different deactivation mechanisms necessitate distinct scaling laws for accurate risk assessment across species.