[Morphology of the reproductive age women cervical epithelium under hypothyreosis]

The purpose of the investigation was to examine the morphological manifestations of hypothyreosis in the reproductive age women cervical mucosa. With clinically verified hypothyreosis in 1524 cases, 538 patients had a different variants of endocervical pathology, accounting for two major research groups: I - (n=259) operated by colloidal goiter treated by L-thyroxin during last 3 years, II - (n=279) with similar diagnosis, without replacement therapy within last 3 years. Therapeutic and diagnostic scrapings from cervix, as well as parallel samples of the operative removal thyroid gland (TG), after staining with hematoxylin and eosin and picrofuchsin by van Gieson were studied morphologically. The different variants of the cervical mucosa reaction from simple hyperplasia in treated group to adenomyosis with stratification of epithelium, and the tendency of sclerosis and atrophy in the group not receiving L-thyroxin were revealed. In all compared cases Spearmen correlation coefficient had high level of relevance (0,00003). We believe that the cervix changes are the consequence of the decrease of sensitivity to estrogen under the low level of T3 and T4 and increase TSH in plasma. Molecular atypia of endocervical cells clearly demon-strates cross-combination of two leading hormonal systems.