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Adenovirus DNA replication

Rob C Hoeben1, Taco G Uil

  • 1Department of Molecular Cell Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands. r.c.hoeben@lumc.nl

Cold Spring Harbor Perspectives in Biology
|February 8, 2013
PubMed

Insights

Adenoviruses are studied for biological processes and gene therapy, but cause disease in immunocompromised individuals. Recent developments include new antivirals targeting human adenovirus (HAdV) replication.

Area of Science:

  • Virology
  • Molecular Biology
  • Gene Therapy

Background:

  • Adenoviruses are versatile tools for studying fundamental biological processes like DNA replication and transcription.
  • Their utility extends to gene-transfer vectors and oncolytic agents in therapeutic applications.
  • However, adenoviruses pose significant risks as pathogens, particularly in immunocompromised populations.

Purpose of the Study:

  • To summarize adenovirus replication strategies and key proteins.
  • To review advancements in adenovirus research since 2006.
  • To discuss the development of antivirals against human adenovirus (HAdV) and their clinical impact.

Main Methods:

  • Review of existing literature on adenovirus biology and replication.
  • Analysis of recent studies (post-2006) on adenovirus applications and pathogenesis.
  • Examination of antiviral strategies targeting HAdV replication.

Main Results:

  • Adenoviruses employ complex replication mechanisms involving specific viral proteins.
  • Significant progress has been made in utilizing adenoviruses for gene therapy and cancer treatment.
  • Development of novel antiviral compounds shows promise in combating HAdV infections.

Conclusions:

  • Adenovirus research continues to evolve, offering insights into viral mechanisms and therapeutic potential.
  • Antiviral development is crucial for managing HAdV diseases, especially in vulnerable patient groups.
  • Understanding HAdV impact on human health remains a key focus for future research and clinical intervention.

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