Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Biosensing using straight long-range surface plasmon waveguides.

Oleksiy Krupin1, Hamoudi Asiri, Chen Wang

  • 1Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, Ontario, Canada.

Optics Express
|February 8, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Hemodynamic effects of synchronous and asynchronous independent lung ventilation with different levels of positive end-expiratory pressure and tidal volumes on unilateral lung injury in dogs].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010
Same author

[Study on the immuno-effects and influencing factors of Chinese hamster ovary (CHO) cell hepatitis B vaccine among adults, under different dosages].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2010
Same author

Assemblies of fluorine containing bent-shaped liquid crystal molecules studied by using scanning tunneling microscopy.

Journal of nanoscience and nanotechnology·2010
Same author

Carbon nanotubes induce secondary structure changes of bovine albumin in aqueous phase.

Journal of nanoscience and nanotechnology·2010
Same author

[Immunogenicity and protective efficacy of pertactin recombinants against Bordetella bronchiseptica challenge].

Wei sheng wu xue bao = Acta microbiologica Sinica·2010
Same author

[Analysis of the electrocardiographic findings in 288 patients with acute pulmonary thromboembolism].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010
Same journal

Denoising algorithm of Φ-OTDR systems based on adaptive fractional wavelet transform denoising.

Optics express·2026
Same journal

Millisecond photon-to-photon latency and high-speed volumetric projection system for optogenetics.

Optics express·2026
Same journal

Polarization-encoded coaxial structured light for high-precision 3D surface profilometry.

Optics express·2026
Same journal

Discrete freeform optical design based on collaborative optimization of point cloud and local normals.

Optics express·2026
Same journal

Ultrafast ghost imaging with 25 GHz speckle switching and wavelength-division multiplexing.

Optics express·2026
Same journal

Atomic vapor cells fabricated by femtosecond laser welding of standard-optical-quality glass.

Optics express·2026
See all related articles

This study presents novel surface plasmon waveguides as sensitive biosensors for detecting cells and proteins. These compact, cost-effective devices offer high signal-to-noise ratios for various biological and chemical analyses.

Area of Science:

  • Photonics and Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Surface plasmon resonance (SPR) biosensors offer high sensitivity for detecting biomolecular interactions.
  • Integrating SPR with waveguide structures can enhance light confinement and sensing performance.
  • Developing cost-effective and compact biosensing platforms is crucial for widespread diagnostic applications.

Purpose of the Study:

  • To demonstrate straight long-range surface plasmon waveguides as effective biosensors.
  • To evaluate the sensor's capability for detecting cells, proteins, and bulk refractive index changes.
  • To assess the biosensor's performance in terms of sensitivity, selectivity, and cost-effectiveness.

Main Methods:

  • Fabrication of gold (Au) stripe waveguides embedded in CYTOP™ polymer with microfluidic channels.

More Related Videos

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Related Experiment Videos

Last Updated: May 14, 2026

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

  • Bulk sensing by injecting solutions with incrementally changing refractive indices (RIU).
  • Selective cell capture using antibody-functionalized waveguides and protein sensing via bovine serum albumin (BSA) adsorption.

    • Main Results:

    • High signal-to-noise ratio (~1000) for detecting refractive index changes in bulk solutions.
    • Selective detection of blood group A red blood cells using antibody functionalization.
    • Detection of a BSA protein monolayer with a signal-to-noise ratio of ~300.
    • Demonstrated sensing across a wide mass range, from cells to proteins.

    Conclusions:

    • The developed surface plasmon waveguides function as versatile and sensitive biosensors.
    • The biosensors exhibit excellent performance for detecting various analytes, including cells and proteins.
    • Their compact, inexpensive nature makes them suitable for cost-sensitive sensing applications.