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Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular

Claire Reeves1, Pelisa Charles-Horvath, Jan Kitajewski

  • 1Department of Ob/Gyn, Columbia University Medical Center, New York, NY 10032, USA. creeves2002@gmail.com

Toxins
|February 8, 2013
PubMed

Insights

Anthrax Toxin Receptors (ANTXRs) are crucial for extracellular matrix homeostasis. Evaluating Antxr knockout mice reveals their physiological roles beyond initial suggestions of angiogenesis.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Anthrax Toxin Receptors (ANTXRs) were initially identified in endothelial cells, implying a role in angiogenesis.
  • The physiological functions of ANTXRs have been further elucidated through studies of knockout mouse models.

Purpose of the Study:

  • To review the physiological roles of Anthrax Toxin Receptors (ANTXRs).
  • To connect ANTXR physiological functions with anthrax intoxication mechanisms.

Main Methods:

  • Analysis of Antxr knockout mouse phenotypes.
  • Review of existing literature on ANTXR function and anthrax.

Main Results:

  • Mice lacking functional Antxr genes exhibit significant defects in extracellular matrix homeostasis.
  • ANTXRs play a critical role in maintaining the integrity of the extracellular matrix.

Conclusions:

  • ANTXRs are essential for extracellular matrix homeostasis.
  • Understanding physiological ANTXR functions provides insights into anthrax pathogenesis.

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