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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: May 14, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

What can we learn from inflammatory bowel disease in developing countries?

Sunny H Wong1, Siew C Ng

  • 1Institute of Digestive Disease, Li Ka Shing Institute of Health Science, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Ngan Shing Street, Shatin, NT, Hong Kong. wonghei@cuhk.edu.hk

Current Gastroenterology Reports
|February 8, 2013
PubMed
Summary

Environmental factors significantly influence Inflammatory Bowel Diseases (IBD) risk in genetically susceptible individuals. Understanding microbiota changes linked to modernization is key to IBD etiology.

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Last Updated: May 14, 2026

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Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Area of Science:

  • Gastroenterology and Immunology
  • Epidemiology

Background:

  • Inflammatory Bowel Diseases (IBD) result from abnormal immune responses to gut antigens in genetically predisposed individuals.
  • Identified genetic factors do not fully explain IBD etiology, highlighting the role of environmental influences.

Purpose of the Study:

  • To explore the impact of environmental factors and lifestyle changes on IBD development.
  • To investigate the role of the gastrointestinal microbiota in IBD pathogenesis.

Main Methods:

  • Review of epidemiological observations and studies on IBD.
  • Analysis of factors associated with societal modernization, including diet, antibiotic use, and hygiene.
  • Consideration of geographic variations and microbiota alterations.

Main Results:

  • Societal modernization, westernized diets, antibiotic use, and hygiene changes are linked to increased IBD incidence.
  • These environmental factors are associated with alterations in the gastrointestinal microbiota, affecting immune system development and IBD risk.
  • Geographic variations indicate differing strengths of risk factor influence.

Conclusions:

  • Environmental factors, particularly those related to modernization and microbiota changes, play a critical role in IBD etiology.
  • Prospective studies in developing countries offer opportunities to elucidate IBD's environmental drivers.