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Urinary concentration of cytokines in children with acute pyelonephritis

Yakubov Renata1, Hassan Jassar, Rina Katz

  • 1Pediatrics Department, Hillel Yaffe Medical Center, Hadera, P.O.B. 169, 38100, Israel.

European Journal of Pediatrics
|February 8, 2013
PubMed

Insights

Interleukin-8 (UIL-8) in urine may predict kidney scarring in children with febrile urinary tract infections (UTIs). Higher UIL-8 levels indicate a greater risk of renal scarring, suggesting its use as a screening tool.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nephrology

Background:

  • Urinary tract infections (UTIs) are common in children, but predicting long-term kidney damage (sequelae) is challenging.
  • Identifying biomarkers for renal scarring in pediatric febrile UTIs is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the predictive value of urine interleukin-6 (UIL-6) and interleukin-8 (UIL-8) concentrations for subsequent renal scarring in children with febrile UTI.

Main Methods:

  • An observational prospective study involving 31 children with a first febrile UTI and 22 febrile children without UTI.
  • Urine samples were analyzed for UIL-6 and UIL-8 concentrations.
  • Renal scarring was assessed, and initial UIL-8 levels were compared between children with and without scarring.

Main Results:

  • UIL-6 and UIL-8 levels were significantly higher in children with febrile UTI compared to controls.
  • Renal scarring was observed in 16% of children with acute pyelonephritis.
  • Initial UIL-8 levels were significantly higher in children who later developed renal scarring.

Conclusions:

  • UIL-8 shows potential as a predictive biomarker for renal scarring following pyelonephritis in children.
  • UIL-8 may serve as a renal-specific diagnostic and prognostic marker for selective screening in febrile UTI cases.

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