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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Tackling the challenges in the total synthesis of landomycin A
Xiaoyu Yang1, Ping Wang, Biao Yu
1State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Abstract:
The twists and turns toward the total synthesis of landomycin A, a prominent angucycline hexasaccharide antibiotic, in particular those toward the stereoselective construction of the di- and trideoxyglycosidic linkages, are described.
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